![]() This effect was also specific to amyloid-β, and not total protein, tau, YKL-40, or hypocretin. This effect was specific for slow wave activity, and not for sleep duration or efficiency. Specific disruption of slow wave activity correlated with an increase in amyloid-β 40 ( r = 0.610, P = 0.009). Data were compared to an identical protocol, with a sham condition during polysomnogram. Seventeen healthy adults (age 35–65 years) without sleep disorders underwent 5–14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-β, tau, total protein, YKL-40, and hypocretin. To date, studies have not examined which aspect of sleep modulates amyloid-β or other Alzheimer’s disease biomarkers. Sleep deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer’s disease pathologies including tauopathy or inflammation. (doi: 10.1093/awx174) for a scientific commentary on this article. Most health insurance plans, including Medicare, cover the diagnosis and treatment of sleep disorders and recognize the benefits of quality sleep to healthy living.See Mander et al. This plan may include medicines, appliances, and counseling. A doctor interprets the results and forms a treatment plan that is specially tailored to your situation. Most studies are done in our comfortable center, but some sleep studies can be done in your home. Small wires are attached to your head and body and you are monitored in an overnight setting as you sleep naturally. Most people are naturally apprehensive about a sleep study, but it is a relatively easy and painless test. A sleep study provides your doctors with comprehensive information about your sleep and breathing. In order to make a complete diagnosis, an overnight sleep study may be necessary. Often, a specialist must observe your sleep habits and symptoms to help determine whether or not a sleep disorder is present. Treatment for sleep disorders can dramatically improve your health and quality of life. Sleep disorders usually don’t go away over time and they often get worse. It’s important to talk to your doctor about your sleep. Studies have found a relationship between sleep and: Many people underestimate the significance of untreated sleep disorders. SLEEP DISORDERS CAN HAVE SERIOUS HEALTH EFFECTS ![]() Suffer frequent leg or arm movements during the night.Have uncomfortable sensations in your legs that keep you awake. ![]()
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